CAAD Research Areas

The Center for Aging and Associated Diseases is a cutting-edge research facility that is designed to investigate the theories and mechanisms of aging and to identify potential interventional strategies to alleviate age-associated deficits. Our major areas of interest include; Redox Neurobiology, cell metabolism and cancer biology. State-of-the-art techniques – including electron paramagnetic resonance spectroscopy, confocal imaging microscopy, magnetic resonance imaging, and optical imaging of live cells and animals – are combined with conventional cell and molecular biology studies, genetic manipulations, as well as behavioral studies at CAAD. The center is also equipped with multiple facilities to monitor metabolic pathways in cell and tissue samples.

Examples of our research interests include, but are not limited to, the following research areas:

The roles of mitochondria in aging and degenerative diseases, including the study of mitochondrial respiratory function, signaling under stress, fission and fusion dynamics, interaction with the nucleus, and apoptosis.
Factors leading to the vulnerability of aged populations to cardiovascular and neurodegenerative diseases and intervention strategies to alleviate that vulnerability.
The sources and dynamics of reactive oxygen species in aging organs.
The interrelation between metabolic disorders, such as diabetes and obesity, and aging.
The mechanism of age-associated cognitive and psychological deficits.
Basic muscle biology in metabolic controls and consequences of aging.
Stem cell technologies and regenerative medicine.
Inflammation in aging and diseases.
Longevity studies.

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