تبرع الآن

النشرات العلمية لمركز علوم الجينوم (CG)

النشرات المختارة

• Ashour M., Atteya R, El-Khamisy S.F (2015). Topoisomerase-mediated chromosomal break repair: an emerging player in many games. Nat Rev Cancer. 15(3):137-51
• Meisenberg, C., Gilbert D.C., Chalmers A., Haley V., Gollins S., Ward S.E., El-Khamisy S.F. (2015). Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan. Mol Cancer Ther. 14(2):575-85
• Carroll, J., Page, T. K. W., Chiang, S.-C., Kalmar, B., Bode, D., Greensmith, L., Hafezparasat, M., El-Khamisy S.F. (2014). Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. Human Molecular Genetics, 24(3):828-40
• Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy S.F *, de Vries BB*, Caldecott KW* (2014). TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nat Genet. 46: 516–52.* Corresponding author.
• Alagoz M, Wells OS, El-Khamisy S.F (2014). TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. Nucleic Acids Res 1; 42(5): 3089-103.
• Walker S, Meisenberg C, Bibby RA, Askwith T, Williams G, Rininsland FH, Pearl LH, Oliver AW, El-Khamisy S.F, Ward S, Atack JR (2014). Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Anal Biochem 14;454C: 17-22.
• Alagoz, M., Chiang, S., Sharma, A., El-Khamisy, S.F (2013). ATM deficiency results in the accumulation of DNA-Topoisomerase I covalent intermediates in neural cells. PLos ONE, 8(4): e58239.