CG Publications

Selected Publications

 

  • Atteya, R., Ashour, M., Ibrahim, E., Farag, M. and El-Khamisy, S. (2016). Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin. Mechanisms of Ageing and Development.
  • Elsayed W, e. (2016). Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1.  - PubMed - NCBI. Ncbi.nlm.nih.gov. Available at: http://www.ncbi.nlm.nih.gov/pubmed/27220325 .
  • Ashour M., Atteya R, El-Khamisy S.F (2015). Topoisomerase-mediated chromosomal break repair: an emerging player in many games. Nat Rev Cancer. 15(3):137-51
  • Meisenberg, C., Gilbert D.C., Chalmers A., Haley V., Gollins S., Ward S.E., El-Khamisy S.F. (2015). Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan. Mol Cancer Ther. 14(2):575-85
  • Carroll, J., Page, T. K. W., Chiang, S.-C., Kalmar, B., Bode, D., Greensmith, L., Hafezparasat, M., El-Khamisy S.F. (2014). Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. Human Molecular Genetics, 24(3):828-40
  • Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy S.F *, de Vries BB*, Caldecott KW* (2014). TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nat Genet. 46: 516–52.* Corresponding author.
  • Alagoz M, Wells OS, El-Khamisy S.F (2014). TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. Nucleic Acids Res 1; 42(5): 3089-103.
  • Walker S, Meisenberg C, Bibby RA, Askwith T, Williams G, Rininsland FH, Pearl LH, Oliver AW, El-Khamisy S.F, Ward S, Atack JR (2014). Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Anal Biochem 14;454C: 17-22.
  • Alagoz, M., Chiang, S., Sharma, A., El-Khamisy, S.F (2013). ATM deficiency results in the accumulation of DNA-Topoisomerase I covalent intermediates in neural cells. PLos ONE, 8(4): e58239.

 

Publications Affiliated to Zewail City

Paper TitleAuthorsJournal/Year 
P18/Stathmin1 is Regulated by miR-31 in Ovarian Cancer in Response to Taxane Hassan MK, Watari H, Mitamura T, Mohamed Z, El-Khamisy SF, Ohba Y, Sakuragi N.

Oncoscience. 2015 23;2(3):294-308

Topoisomerase-mediated Chromosomal Break Repair: An Emerging Player in Many Games Ashour ME, Atteya R, El-Khamisy SF.

Nat Rev Cancer. 2015 15(3):137-51

Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to Irinotecan Meisenberg C, Gilbert DC, Chalmers A, Haley V, Gollins S, Ward SE, El-Khamisy SF.

Mol Cancer Ther. 2015 14(2):575-85

Expression of a Pathogenic Mutation of SOD1 Sensitizes Aprataxin-deficient Cells and Mice to Oxidative Stress and Triggers Hallmarks of Premature Ageing Carroll J, Page TK, Chiang SC, Kalmar B, Bode D, Greensmith L, Mckinnon PJ, Thorpe JR, Hafezparast M, El-Khamisy SF.

Hum Mol Genet. 2015 1;24(3):828-40