Sameh Saad Ali

academic title

Professor of biophysics

Contact Information

Email: sameh.ali@zewailcity.edu.eg

Admin Support

Ms Maha Ahmed 
Email: mahmed@zewailcity.edu.eg

Professor Sameh Saad Ali is a professor of biophysics at the Center for Aging and Associated Diseases (CAAD), Zewail City of Science and Technology. He is also an assistant professor (on sabbatical) at the University of California, San Diego, U.S.

Ali graduated with a Bachelor of Science degree in chemistry from the Faculty of Science, Ain Shams University, Egypt in 1988. He completed his Master of Science degree in photochemistry in 1994 at Tohoku University, Japan, followed by his Doctor of Philosophy degree in 1997.

Ali began his career as a researcher, instructor and then lecturer of physical chemistry at Ain Shams University. In 1998 he served as a visiting postdoctoral fellow at Granz University of Technology in Austria. From 2000 to 2005, Ali held different positions at Washington University in Saint Louis (U.S.). From 2000 to 2003, he served as a postdoctoral fellow in the chemistry department. Meanwhile, in 2002, he was appointed as a lecturer, instructor and teaching assistant of chemistry summer courses. He then joined the neurology department as a research associate. Joining the University of California, San Diego in 2005, Ali worked as an assistant research scientist for three years. He also acts as an executive editor, editor, and regular reviewer for tens of internationally reputable journals.

Ali, a formally trained physical chemist, started to take interest in free radical biology and medicine in 2003 while exploring the extraordinary antioxidant properties of fullerenes in vitro and in vivo. The elegance and complexity of the mitochondrion fascinated Ali that he made a career shift to study the critical roles of mitochondria in aging and diseases.

During his work in the departments of medicine and anesthesiology at the University of California, Ali contributed to many projects in the field of mitochondria function and free radical biology and medicine. His work produced over 50 highly cited articles in high-impact journals including Science, Proceedings of the National Academy of Sciences, Aging Cell, Antioxidant & Redox Signaling, The FASEB Journal, The Journal of Neuroscience, and Free Radical Biology & Medicine.

Ali graduated with a Bachelor of Science degree in chemistry from the Faculty of Science, Ain Shams University, Egypt in 1988. He completed his Master of Science degree in photochemistry in 1994 at Tohoku University, Japan, followed by his Doctor of Philosophy degree in 1997.

Ali, a formally trained physical chemist, started to take interest in free radical biology and medicine in 2003 while exploring the extraordinary antioxidant properties of fullerenes in vitro and in vivo. The elegance and complexity of the mitochondrion fascinated Ali that he made a career shift to study the critical roles of mitochondria in aging and diseases.

  • Ali SS, Hardt JI, Quick KL, Kim-Han JS, Erlanger BF, Huang T, Epstein CJ and Dugan LL. (2004) A Biologically Effective Fullerene (C60) Derivative with Superoxide Dismutase Mimetic Properties. Free Rad. Biol. Med., 37:1191-1202.
  • Behrens MM, Ali SS, Dao DN, Lucero J, Shekhtman G, Quick, KL, Dugan, LL. (2007) Brain NADPH-oxidase mediates ketamine effects on parvalbumin-expressing fast-spiking interneurons. Science 318:1645-1647.
  • Ali SS*, Hardt JI, and Dugan LL (2008) SOD activity of carboxyfullerenes predicts their neuroprotective efficacy: A structure-activity study. Nanomedicine: Nanotechnology, Biology, and Medicine, 4(4):283-294.
  • Ali SS*, Marcondes, MC, Bajova, H, and Conti, B. (2010) Metabolic depression and increased reactive oxygen species production by isolated mitochondria at moderately lower temperatures. J. Biol. Chem., 285(42):32522-8.
  • Dugan LL, You Y-H, Ali SS, Diamond-Stanic M, Miyamoto S, DeCleves A-E, Andreyev A, Quach T, Ly S, Shekhtman G, Nguyen W, Chepetan A, Le TP, Wang L, Xu M, Paik KP, Fogo A, Viollet B, Murphy A, Brosius F, Naviaux RK, and Sharma K (2013) Mitochondrial Function and Superoxide Production is Reduced in the Diabetic Kidney and Restored by AMPK Activation. J. Clinical Investigations. 123 (11), 4888.
Visit us
Apply now
Give